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Cyramza ® (ramucirumab)
This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information. For current prescribing information for all Lilly products, including Summaries of Product Characteristics, Patient Information Leaflets and Instructions for Use, please visit: www.medicines.org.uk (England, Scotland, Wales) or www.emcmedicines.com/en-GB/northernireland/ (Northern Ireland).
How do I manage extravasation with Cyramza® (ramucirumab)?
If extravasation occurs or is suspected, follow your local procedures for managing non-vesicant extravasation or use local cold compresses.
Recommendations from the European Society for Medical Oncology - The European Oncology Nursing Society (ESMO-EONS)
The European Society for Medical Oncology-The European Oncology Nursing Society (ESMO-EONS) Clinical Practice Guidelines recommend using local dry cold compresses for non-vesicants such as ramucirumab if extravasation does occur.1
Cyramza is not a vesicant
Ramucirumab is a non-vesicant as it is an antibody in a neutral formulation. It is not likely to cause extravasation.
No dedicated extravasation studies have been conducted in animals. However, local tolerance was investigated in 2 repeat-dose toxicity evaluations in cynomolgus monkeys by clinical observations and as part of the histopathological evaluations.
Intravenous administration of ramucirumab was well tolerated at all dose levels.
Mild, local injection-site reactions were observed and consisted of mononuclear and/or polymorphonuclear cells in the perivascular areas.2
1Perez Fidalgo JA, Garcia Fabregat L, Cervantes A, et al. Management of chemotherapy extravasation: ESMO-EONS Clinical Practice Guidelines. Ann Oncol. 2012;Suppl 7:vii167-73. http://annonc.oxfordjournals.org/content/23/suppl_7/vii167
2Data on file, Eli Lilly and Company and/or one of its subsidiaries.
Date of Last Review: 25 April 2022