Tips for searching:
• You have to select a product and type at least 2 words to activate the search
• Use only words that are specific to the information you are looking for
• Avoid typing questions or sentences
Please do not use this field to report adverse events or product complaints. Adverse events and product complaints should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard or search for MHRA Yellow card in the Google play or Apple app store. Adverse events and product complaints should also be reported to Lilly: please call Lilly UK on 01256 315 000.
Trulicity ® (dulaglutide)
This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information. For current prescribing information for all Lilly products, including Summaries of Product Characteristics, Patient Information Leaflets and Instructions for Use, please visit: www.medicines.org.uk (England, Scotland, Wales) or www.emcmedicines.com/en-GB/northernireland/ (Northern Ireland).
Does Trulicity® (dulaglutide) have an effect on pancreatic enzyme levels?
In the 9 registration clinical studies, dulaglutide treatment increased pancreatic enzymes. The changes in pancreatic enzymes were dose dependent and greater for dulaglutide 1.5 mg than dulaglutide 0.75 mg.
What changes in lipase and p-amylase levels were seen with dulaglutide?
The median changes in lipase ranged from
- 5.0 to 7.0 units/L with dulaglutide 1.5 mg, and
- 3.0 to 5.0 units/L with dulaglutide 0.75 mg.
Median levels in lipase also increased with sitagliptin, exenatide twice daily, and metformin. A small decrease in the median level in lipase was noted with Insulin glargine. A small decrease to no change was noted with placebo.1
The median changes in p-amylase ranged from
- 3.0 to 5.0 units/L with dulaglutide 1.5 mg, and
- 2.0 to 4.0 units/L with dulaglutide 0.75 mg.
Median levels in p-amylase also increased with sitagliptin, exenatide twice daily, metformin, and Insulin glargine. The median level in p-amylase did not change with placebo.1
1Nauck MA, Frossard JL, Barkin JS, et al. Assessment of pancreas safety in the development program of once-weekly GLP-1 receptor agonist dulaglutide. Diabetes Care. 2017;40(5):647-654. http://dx.doi.org/10.2337/dc16-0984
Date of Last Review: 02 August 2023